H8502
Dopamine hydrochloride
≥98% (TLC), powder, neurotransmitter
Synonym(s):
2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride
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About This Item
Linear Formula:
(HO)2C6H3CH2CH2NH2·HCl
CAS Number:
Molecular Weight:
189.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-527-8
MDL number:
Beilstein/REAXYS Number:
3656720
Form:
powder
Quality level:
Product Name
Dopamine hydrochloride,
form
powder
Quality Level
color
, White to Light Yellow to Light Beige
mp
248-250 °C (lit.)
solubility
alcohol: 20 mg/mL, H2O: soluble
storage temp.
2-8°C
SMILES string
Cl[H].NCCc1ccc(O)c(O)c1
InChI
1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
InChI key
CTENFNNZBMHDDG-UHFFFAOYSA-N
Gene Information
human ... ADRB1(153)
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General description
Dopamine (DA) works as a neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in the vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. The Absence of DA-containing neurons is associated with Parkinson’s disease.Dopamine is produced and released by the dopaminergic neurons in the substantia nigra that is in the central nervous system. It is involved in several activities such as movement, behaviour, learning, reward, punishment, dreaming, working, memory, mood, sleep, attention, and inhibition of prolactin production. Dopamine also acts as a precursor in the synthesis of catecholamines like epinephrine and norepinephrine. Increased levels of dopamine via the tuberoinfundibular pathway are associated with Schizophrenia, hallucinations, euphoria, and psychosis. A deficiency of dopamine and norepinephrine indicates the neurochemical basis for attention-deficit hyperactivity disorder (ADHD), a pediatric disorder.
Application
Dopamine hydrochloride has been used:
- to study dopamine-mediated transient modulation of the physiological responses in white leg shrimp, Litopenaeus vannamei.
- to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
- to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease.
- as a substrate of the prophenoloxidase (PPO) cascade reaction in the anti-microbial assay targeting methicillin-resistant staphylococcus aureus (MRSA) in the biofilm phase.
- added exogenously to the culture medium to study its effect on H. contortus female worms.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Saad Latif et al.
Clinica chimica acta; international journal of clinical chemistry, 522, 114-126 (2021-08-15)
Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie, cells critical to the production of dopamine, an important neurotransmitter in the brain. Here, we present a brief review of the dopamine synthetic pathway, binding to the
Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis
Xue R, et al.
Frontiers in Immunology, 9, 2398-2398 (2018)
Rafael Franco et al.
Biomedicines, 9(2) (2021-01-28)
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors. Dopamine has been studied
Dopamine depresses the immune ability and increases susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
Li JT et al.
Fish & Shellfish Immunology, 19, 269-269 (2005)
Flow injection with inhibited chemiluminescence method for the determination of dopamine hydrochloride.
Shuhao WANG et al.
Analytical Sciences, 20, 315-317 (2004)
Articles
DISCOVER Bioactive Small Molecules for Neuroscience
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H8502-5G | 04061835253333 |
| H8502-100G | 04061835253319 |
| H8502-10G | 04061833810682 |
| H8502-25G | 04061835253326 |
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