H8909
HBcAg core human
~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli
Synonym(s):
Hepatitis B virus core antigen
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
mol wt
18 kDa
concentration
~1 mg/mL
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
hepatitis B virus ... HBVgp4(944568)
human ... HBVgp4(944568)
General description
amino acids 1-183 of HBV core antigen.
Biochem/physiol Actions
HBcAg core human is a capsid protein of hepatitis B virus (HBV). It acts as a viral factor for HBV clearance. HBcAg is implicated in viral replication.
Hepatitis B virus core antigen (HBcAg) is a positive control for human HBV antibodies.In humans with chronic HBV (hepatitis B virus) infection, cytotoxic effects of blood T lymphocytes can be suppressed by incubating cells with antibodies against hepatitis B core antigen (HBcAg). The antigen can also work as a T-cell independent antigen in athymic mice. However, it is an efficient immunogen, resulting in T-cell activation and increased anti-HBc levels. High cytoplasmic/membranous expression of HBcAg is associated with increased liver inflammation.
Physical form
Solution in 50% glycerol, 7.5 mM phosphate buffer, pH 7.2, 75 mM NaCl.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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M Mondelli et al.
Journal of immunology (Baltimore, Md. : 1950), 129(6), 2773-2778 (1982-12-01)
Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly increased in 13 cases, and in 12 of these the cytotoxic effect of the T lymphocytes was
Jun Hong et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 38(4), 362-373 (2007-11-21)
This study was undertaken to investigate whether plasmacytoid dendritic cells (PDC) are involved in the generation of a higher proportion of CD4(+) and CD25(+) regulatory T (Treg) cells in chronic hepatitis B virus (HBV) infection compared with healthy patients. The
Hepatitis B virus nucleocapsid but not free core antigen controls viral clearance in mice
Lin YJ, et al.
Journal of Virology, 86(17), 9266-9273 (2012)
C M Chu et al.
Gastroenterology, 92(1), 220-225 (1987-01-01)
The intrahepatic distribution of hepatitis B core antigen (HBcAg) and surface antigen (HBsAg) was studied in 32 patients with chronic type B hepatitis, and the results were correlated with the status of hepatitis B e antigen/antibody (HBeAg/anti-HBe) and with the
D R Milich et al.
Journal of immunology (Baltimore, Md. : 1950), 139(4), 1223-1231 (1987-08-15)
Hepatitis B virus nucleocapsid particles (HBcAg) can function as a T cell-independent antigen when injected into athymic mice. However, immunization of euthymic mice with HBcAg results in dramatically increased anti-HBc titers. Therefore we have examined the murine T cell response
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