H9538
HNE-DMA
hexane solution, ≥85% (GC)
Synonym(s):
(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA
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About This Item
Empirical Formula (Hill Notation):
C11H22O3
Molecular Weight:
202.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥85% (GC)
form
hexane solution
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCC(O)\C=C\C(OC)OC
InChI
1S/C11H22O3/c1-4-5-6-7-10(12)8-9-11(13-2)14-3/h8-12H,4-7H2,1-3H3/b9-8+
InChI key
ATGIHMSJAARJTF-CMDGGOBGSA-N
Biochem/physiol Actions
Stable form of HNE; toxic second messenger of free radicals.
Preparation Note
To prepare HNE from HNE-DMA: evaporate the hexane under a gentle stream of nitrogen at room temperature. Working at 4 °C, add 1 ml (5 mg size) or 0.4 ml (2 mg size) of 1 mM cold HCl and stir for 45 minutes, or alternatively, close the vial and shake for 30 minutes. Upon hydrolysis, the initially cloudy solution becomes almost clear. This solution now has a pH of ∼3, contains ∼5 mg (5 mg size) or ∼2 mg (2 mg size) of the aldehyde (HNE), and is stable for at least 24 hours if kept at 4 °C. 6.8 mg HNE-DMA in 1 mL of hexane solution, giving 5 mg of HNE after hydrolysis.It is recommended that the freshly prepared HNE solution be used immediately.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
Target Organs
Central nervous system, Nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
-14.8 °F - closed cup
Flash Point(C)
-26 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
危险化学品
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