I0779
Interleukin-2 Soluble Receptor α human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
CD25, IL-2 sRα, Tac antigen
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About This Item
biological source
human
Quality Segment
recombinant
expressed in NSO cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.5-1.0 mg per mL ED50
mol wt
36 kDa by SDS-PAGE
packaging
pkg of 5 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL2RA(3559)
Biochem/physiol Actions
Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.
Analysis Note
The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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