I0782
Imazodan
≥99% (HPLC)
Synonym(s):
4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914
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About This Item
Empirical Formula (Hill Notation):
C13H12N4O
CAS Number:
Molecular Weight:
240.26
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
Assay
≥99% (HPLC)
color
yellow, powder
solubility
DMSO: 50 mg/mL, clear, yellow
SMILES string
O=C1CCC(=NN1)c2ccc(cc2)-n3ccnc3
InChI
1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
InChI key
VXMYWVMXSWJFCV-UHFFFAOYSA-N
Gene Information
human ... PDE3A(5139)
rat ... Pde3a(50678)
Biochem/physiol Actions
Selective phoshodiesterase III (PDE3) inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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R E Weishaar et al.
Journal of cyclic nucleotide and protein phosphorylation research, 10(6), 551-564 (1985-01-01)
In the present study, the inhibitory effects of CI-914, a novel cardiotonic agent, as well as other recently identified positive inotropic agents and reference phosphodiesterase (PDE) inhibitors on the different molecular forms of cardiac PDE were examined, and correlated with
A Hartmann et al.
Cardiovascular research, 21(8), 593-600 (1987-08-01)
Isolated rabbit coronary arteries, aortic strips, and a working rabbit heart preparation were used to assess the positive inotropic and vasodilator effects of a newly developed positive inotropic compound, CI 914. The substance had a relaxing effect on histamine preconstricted
A D Goldberg et al.
The American journal of cardiology, 68(6), 631-636 (1991-09-01)
A 12-week, multicenter, double-blind, randomized, placebo-controlled trial of imazodan, a type III phosphodiesterase inhibitor, was conducted in 147 patients with congestive heart failure to determine clinical efficacy and safety. Patients were randomized to placebo or 2, 5 or 10 mg
S Terris et al.
The American journal of cardiology, 58(7), 596-600 (1986-09-15)
The hemodynamic effects of CI-914, a phosphodiesterase inhibitor, were studied in 12 patients with left ventricular (LV) dysfunction who were undergoing diagnostic cardiac catheterization. CI-914 was infused intravenously at a rate of 0.8 to 7.0 micrograms/kg/min for 30 to 60
I Sircar et al.
Journal of medicinal chemistry, 30(10), 1724-1728 (1987-10-01)
A series of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones was synthesized and evaluated for positive inotropic activity. Only compounds with two small alkyl groups at C-4 showed significant activity. The structure-activity relationships for optimal inotropic activity are presented and compared with those of the 4,5-dihydro-3(2H)-pyridazinone
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