I127
ICI 118,551 hydrochloride
≥98% (HPLC), powder, β2 inverse agonist
Synonym(s):
(2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H27NO2 · HCl
CAS Number:
Molecular Weight:
313.86
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
ICI 118,551 hydrochloride, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >10 mg/mL
SMILES string
Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
InChI
1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1
InChI key
KBXMBGWSOLBOQM-LINSIKMZSA-N
Gene Information
human ... ADRB2(154)
Application
ICI 118,551 hydrochloride has been used:
- to block β-adrenergic signaling in various experiments
- to counteract degradation by endogenous T-lymphocyte monoamine oxidases
- to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts
Biochem/physiol Actions
ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.
ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Analysis of ICI 118551, a new beta2 blocking drug, and related compounds by RP-HPLC?DAD
Quaglia MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 10(10-12), 1081-1084 (1992)
beta-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum
Lamkin DM, et al.
Brain, behavior, and immunity, 57(, 338-346 (2016)
R M Booze et al.
The Journal of pharmacology and experimental therapeutics, 249(3), 911-920 (1989-06-01)
The localization and number of beta adrenergic receptors were directly compared in the brains of rats and guinea pigs. The time course of association and saturability of [125I]cyanopindolol (CYP) binding to slide-mounted tissue sections was similar in rats (Kd =
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I127-5MG | 04061833847596 |
| I127-25MG | 04061832091365 |