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Merck
CN

I134

L-N5-(1-Iminoethyl)ornithine hydrochloride

≥95% (HPLC)

Synonym(s):

L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C7H15N3O2 · xHCl
CAS Number:
852173-80-9
Molecular Weight:
173.21 (free base basis)
NACRES:
NA.26
PubChem Substance ID:
329815348
UNSPSC Code:
12352204
MDL number:
MFCD00153817
Form:
powder
Assay:
≥95% (HPLC)
Mol wt:
calculated mol wt 173.22 g/mol

Key Documents

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InChI key

JIBZSGQTCBWUKL-RGMNGODLSA-N

SMILES string

CC(NCCC[C@H](N)C(O)=O)=N.[H]Cl

InChI

1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1

assay

≥95% (HPLC)

form

powder

mol wt

calculated mol wt 173.22 g/mol

storage condition

desiccated, under inert gas

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

−20°C

Quality Level

100

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Application

L-N5-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect. It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed.

Biochem/physiol Actions

A potent irreversible inhibitor of nitric oxide synthase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000280829
0000280827
0000246101
0000280827
0000280829

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International Review of Neurobiology, 42 (1998)
The effects of sufentanil in the feline pulmonary vascular bed
Alan D Kaye
European Journal of Pharmacology (2006)
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase
Alejandro Javier Espa?ol
International Immunopharmacology, 29(1) (2015)

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