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Merck
CN

I135

Imetit dihydrobromide

≥98% (HPLC)

Synonym(s):

S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C6H10N4S · 2HBr
CAS Number:
32385-58-3
Molecular Weight:
332.06
NACRES:
NA.77
PubChem Substance ID:
24277783
UNSPSC Code:
12352200
MDL number:
MFCD00153816

Key Documents

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Product Name

Imetit dihydrobromide, ≥98% (HPLC)

InChI

1S/C6H10N4S.2BrH/c7-6(8)11-2-1-5-3-9-4-10-5;;/h3-4H,1-2H2,(H3,7,8)(H,9,10);2*1H

SMILES string

Br[H].Br[H].NC(=N)SCCc1c[nH]cn1

InChI key

DOBOYMKCRRLTRF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

Quality Level

100

Gene Information

human ... HRH3(11255)

Related Categories

Biochem/physiol Actions

Potent and selective H3 histamine receptor agonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000077589
0000077588
0000040632
0000039692
104M4744V

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M Garbarg et al.
The Journal of pharmacology and experimental therapeutics, 263(1), 304-310 (1992-10-01)
The effects of a new agonist of histamine (HA) H3 receptors, Imetit (S-[2-(4-(imidazolyl)ethyl]isothiourea) were investigated in vitro and in vivo and compared to those of (R)-alpha-methylhistamine [(R)-alpha-MeHA], a prototypic drug. Imetit inhibited the binding of [3H](R-alpha-MeHA to rat brain membranes
Balasubramaniam Annamalai et al.
ACS chemical neuroscience, 11(3), 466-476 (2020-01-10)
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H3 histamine receptors (H3Rs)
Carina Höring et al.
International journal of molecular sciences, 21(22) (2020-11-14)
In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of GPCR-G protein interactions and G protein activation by means of
Nayeli Rivera-Ramírez et al.
Neurochemistry international, 101, 38-47 (2016-11-05)
The histamine H3 receptor (H3R) is abundantly expressed in the Central Nervous System where it regulates several functions pre and postsynaptically. H3Rs couple to Gαi/o proteins and trigger or modulate several intracellular signaling pathways, including the cAMP/PKA pathway and the

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