I1395
IL-6 human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
Interleukin-6 human, hIL-6, IL-6
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About This Item
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
26 kDa
Impurities:
≤1.000 EU/μg
Product Name
Interleukin-6 human, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
Quality Segment
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
0.2-2.0 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
26 kDa
packaging
pkg of 10 and 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
General description
Recombinant human Interleukin‑6 (IL‑6) is an immunomodulatory cytokine expressed in Escherichia coli and supplied as a lyophilized powder. IL‑6 is commonly used in mammalian cell culture research involving immune cell growth and activation studies in vitro.
Application
IL-6 has been used in mammalian cell culture research applications, including immune‑related cell signaling, activation, cytokine‑response studies in vitro, proliferation of T lymphocytes and hematopoietic progenitors.
Biochem/physiol Actions
Interleukin-6 (IL-6) is a multifunctional protein directly involved in the responses that occur after infection and is as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes.
Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
Physical form
Lyophilized from a 0.2 μm filtered solution of phosphate buffer saline (PBS), pH 7.4, containing 500 μg bovine serum albumin.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
flash_point_f
Not applicable
flash_point_c
Not applicable
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