I1411
ITX3
≥98% (HPLC)
Synonym(s):
2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one
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About This Item
Empirical Formula (Hill Notation):
C22H17N3OS
CAS Number:
Molecular Weight:
371.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ≥4 mg/mL
storage temp.
room temp
SMILES string
Cc1cc(\C=C2\Sc3nc4ccccc4n3C2=O)c(C)n1-c5ccccc5
InChI
1S/C22H17N3OS/c1-14-12-16(15(2)24(14)17-8-4-3-5-9-17)13-20-21(26)25-19-11-7-6-10-18(19)23-22(25)27-20/h3-13H,1-2H3/b20-13+
InChI key
SJMYMKPBODEZSH-DEDYPNTBSA-N
Biochem/physiol Actions
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.
ITX3 is a specific inhibitor of endogenous TrioN activity; selective cell active inhibitor of the Trio/RhoG/Rac1 pathway.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Kiran A Vaidya et al.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 58, 107414-107414 (2022-01-26)
Calcific aortic valve disease (CAVD), a major cause for surgical aortic valve replacement, currently lacks available pharmacological treatments. Cadherin-11 (Cad11), a promising therapeutic target, promotes aortic valve calcification in vivo, but direct Cad11 inhibition in clinical trials has been unsuccessful.
J-W Jang et al.
Oncogene, 36(7), 999-1011 (2016-07-19)
The tumor-suppressor RUNX3 has a critical role in a lineage determination, cell cycle arrest and apoptosis. Lozenge (Lz), a Drosophila homolog of mammalian RUNX family members, has integral roles in these processes and specifically in eye cell fate determination. To
Jos Van Rijssel et al.
Biology open, 2(6), 569-579 (2013-06-22)
Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleton, but are also implicated in gene regulation. However, in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I1411-25MG | 04061833219133 |
| I1411-5MG | 04061833219140 |