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I148

Imperatoxin A

Name: Imperatoxin A
Brand: SIGMA

>88%, lyophilized powder

Synonym(s):

Ip Txa

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About This Item

Empirical Formula (Hill Notation):

C₁₄₈H₂₆₀N₅₈O₄₅S₆

CAS Number:

172451-37-5

Molecular Weight:

3764.40

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD01323698

Assay:

>88%

Form:

lyophilized powder

Quality level:

200

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Quality Level

200

assay

>88%

form

lyophilized powder

storage temp.

−20°C

Biochem/physiol Actions

Selective skeletal-type ryanodine sensitive intracellular Ca²⁺ channel activator found in the scorpion Pandinus

Selective skeletal-type ryanodine sensitive intracellular Ca²⁺ channel activator.

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.

F Z Zamudio et al.

FEBS letters, 405(3), 385-389 (1997-04-01)

We present the complete amino acid sequence of Imperatoxin A (IpTx(a)), a 33-amino-acid peptide from the venom of the scorpion P. imperator which activates Ca2+ release channels/ryanodine receptors (RyR) of sarcoplasmic reticulum (SR). The amino acid sequence of IpTx(a) shows

Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle.

H H Valdivia et al.

Proceedings of the National Academy of Sciences of the United States of America, 89(24), 12185-12189 (1992-12-15)

We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-release channels. Imperatoxin inhibitor has a M(r) of approximately 10,500, inhibits [3H]ryanodine binding to skeletal

Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms.

R el-Hayek et al.

The Journal of biological chemistry, 270(48), 28696-28704 (1995-12-01)

We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of the scorpion Pandinus imperator (Valdivia, H. H., Kirby, M. S., Lederer

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