I1507
Insulin human
≥95% (HPLC), semisynthetic, powder, non-sterile
biological source
semisynthetic
Quality Level
sterility
non-sterile
Assay
≥95% (HPLC)
form
powder
concentration
>75%
technique(s)
cell culture | mammalian: suitable
solubility
0.01 M HCl: 0.5 mg/mL, clear to slightly hazy, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N8CCC[C@H]8C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CNC=N2)CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)[C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CN
InChI key
PBGKTOXHQIOBKM-FHFVDXKLSA-N
Gene Information
human ... INS(3630)
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Related Categories
General description
Insulin binds to the receptors of target cells in the liver, skeletal muscle and fat, b cells, brain cells, and many other cells. The insulin gene is located on human chromosome 11p15.5.
Application
- in artificial cerebrospinal fluid (aCSF) to study the effect of preoptic area administration of insulin on core body temperature (CBT) in mice
- in contact-mode scanning probe electrospray ionization (SPESI) to study the effect of substrate vibration on ionization efficiency
- as a component of adipocyte differentiation media
Biochem/physiol Actions
Insulin signaling is associated with two important pathways namely: phosphatidylinositol 3-kinase (PI3K, a lipid kinase)/AKT (also known as PKB or protein kinase B) pathway and the Raf/Ras/MEK/ MAPK (mitogen-activated protein kinase, also known as ERK or extracellular signal-regulated kinase) pathway. Insulin increases the metabolic pathways controlling glycogen synthesis, gene expression, DNA synthesis, and Na+/K+ pump. It inhibits metabolic pathways regulating apoptosis and autophagy.
Other Notes
Preparation Note
antibody
related product
Storage Class Code
11 - Combustible Solids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Regulatory Information
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Protocols
Insulin is an approximately 6000 Da peptide hormone used to regulate the glucose concentration in blood. There are several different forms of insulin that are both natural and recombinant; the recombinant forms have been engineered to improve pharmacokinetic properties. A quick and reliable chromatographic technique was developed to identify and detect a mixture of insulin variants in an unknown sample.
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