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I1786

ID-8

≥98% (HPLC)

Synonym(s):

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

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About This Item

Empirical Formula (Hill Notation):
C16H14N2O4
CAS Number:
147591-46-6
Molecular Weight:
298.29
NACRES:
NA.77
PubChem Substance ID:
329815358
UNSPSC Code:
12352200
MDL number:
MFCD00593367
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)-n2c(C)c([N+]([O-])=O)c3ccc(O)cc23

InChI

1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3

InChI key

VVZNWYXIOADGSW-UHFFFAOYSA-N

General description

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

Biochem/physiol Actions

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
Sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

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