I2285
IPA-3
≥95% (HPLC), powder
Synonym(s):
1,1′-Disulfanediyldinaphthalen-2-ol
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About This Item
Empirical Formula (Hill Notation):
C20H14O2S2
CAS Number:
Molecular Weight:
350.45
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
powder
color
off-white to yellow
solubility
DMSO: >20 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
InChI
1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChI key
RFAXLXKIAKIUDT-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
IPA-3 is an allosteric inhibitor of Pak1.
IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Aniruddha Das et al.
Scientific reports, 7(1), 13930-13930 (2017-10-27)
Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA). Rac GTPase and its downstream effector p21-activated kinase (PAK)
Elena G Sánchez et al.
PLoS pathogens, 8(6), e1002754-e1002754 (2012-06-22)
African swine fever (ASF) is caused by a large and highly pathogenic DNA virus, African swine fever virus (ASFV), which provokes severe economic losses and expansion threats. Presently, no specific protection or vaccine against ASF is available, despite the high
Mathilde Gavillet et al.
American journal of hematology, 93(2), 269-276 (2017-11-11)
NET formation in mice (NETosis) is supported by reactive oxygen species (ROS) production by NADPH oxidase and histone hypercitrullination by peptidylarginine deiminase 4 (PAD4). Rac1 and Rac2, expressed in polymorphonuclear neutrophils (PMNs), regulate the cytoskeleton, cell shape, adhesion, and migration
Kemal Keseroglu et al.
Nature communications, 14(1), 6497-6497 (2023-10-15)
Mutations of several genes cause incomplete penetrance and variable expressivity of phenotypes, which are usually attributed to modifier genes or gene-environment interactions. Here, we show stochastic gene expression underlies the variability of somite segmentation defects in embryos mutant for segmentation
Florian Ingo Schmidt et al.
The EMBO journal, 30(17), 3647-3661 (2011-07-28)
Vaccinia virus (VACV), the model poxvirus, produces two types of infectious particles: mature virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and therefore require an unusual cellular entry mechanism. By a combination of fluorescence and electron microscopy
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