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I2393

IL-1β rat

Name: IL-1β rat
Brand: SIGMA

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IL-1β, Interleukin-1β from rat, Lymphocyte activating factor

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD01094098

Biological source:

rat

Recombinant:

expressed in E. coli

Assay:

≥98% (SDS-PAGE and HPLC)

Form:

lyophilized powder

Mol wt:

17.3 kDa

Impurities:

<0.1 EU/μg

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Properties

Product Name

Interleukin-1β from rat, IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

rat

Quality Level

100

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

0.01-0.1 ng/mL ED₅₀/EC₅₀

mol wt

17.3 kDa

packaging

pkg of 10 and 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg

UniProt accession no.

Q63264

storage temp.

−20°C

Gene Information

rat ... Il1b(24494)

Description

General description

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cells and lymphocytes, which then proliferate and secrete interleukin-2.¹ IL-1 is primarily released from stimulated macrophages and monocytes, but is also released from several other cell types,² and is thought to play a key role in inflammatory and immune responses.³ Other synonyms for IL-1 include: Endogenous Pyrogen (EP), Mitogenic Protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRF_H), B cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF).⁴ The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence. Recombinant rat IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution.

Analysis Note

The biological activity is measured in a cell proliferation assay using murine D10S cells.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Articles

Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

Global Trade Item Number

SKU	GTIN
I2393-10UG	04061833848449
I2393-50UG	04061833848456