I2406
IL-11 human
>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Synonym(s):
Interleukin-11 human, IL-11
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About This Item
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
23 kDa
Impurities:
endotoxin, tested
Product Name
Interleukin-11 human, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
biological source
human
Quality Segment
recombinant
expressed in baculovirus infected Sf21 cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.06-0.24 ng/mL ED50
mol wt
23 kDa
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL11(3589)
General description
Biochem/physiol Actions
Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.
Physical form
Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.
Analysis Note
The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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