I2526
Insulin-like Growth Factor-II human
IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
IGF-II
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About This Item
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
monomer 7.5 kDa ((67 aa))
Impurities:
≤0.1 EU/μg (LAL test)
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤6 ng/mL ED50
quality
endotoxin tested
mol wt
monomer 7.5 kDa ((67 aa))
packaging
pkg of 5X50 μg, pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤0.1 EU/μg (LAL test)
UniProt accession no.
storage temp.
−20°C
Biochem/physiol Actions
IGF-II, also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. IGF-II binds to the IGF-II receptor, IGF-I receptor, and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-I receptor. However, during embryogenesis the roles of both IGF-II receptor and IR may be significant in promoting normal growth.
Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.
Physical form
Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA).
Preparation Note
Reconstitute with sterile water at 0.1 mg/mL
Analysis Note
The biological activity is measured by a cell proliferation assay using Human breast cancer cell line MCF-7
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Articles
Insulin-like Growth Factors (IGF)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| I2526-5X50UG | 04061833848548 |
| I2526-50UG | 04061833848531 |