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I3159

IMD-0354

Name: IMD-0354
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₈ClF₆NO₂

CAS Number:

978-62-1

Molecular Weight:

383.67

NACRES:

NA.77

PubChem Substance ID:

24724513

UNSPSC Code:

12352200

MDL number:

MFCD00218820

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >20 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F

InChI

1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)

InChI key

CHILCFMQWMQVAL-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Application

IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.

Biochem/physiol Actions

IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. ^[4]

Packaging

Light sensitive. Packaged under nitrogen.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000472191

0000326300

0000196172

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Investigating mechanisms of angiogenesis in health and disease using zebrafish models, 24-25 (2018)

TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.

Zhen-Yu Ma et al.

Biochemical and biophysical research communications, 471(4), 576-581 (2016-02-14)

Activated fibroblasts continue to proliferate at injury sites, leading to progressive muscular fibrosis in Duchenne muscular dystrophy (DMD). TGF-β1 is a dominant profibrotic mediator thought to play a critical role in muscle fibrosis; however, the implicated mechanisms are not fully

LINC01410-miR-532-NCF2-NF-kB feedback loop promotes gastric cancer angiogenesis and metastasis.

Jia-Xing Zhang et al.

Oncogene, 37(20), 2660-2675 (2018-02-28)

Dysregulation of non-coding RNAs, including miRNAs and lncRNAs has been reported to play vital roles in gastric cancer (GC) carcinogenesis, but the mechanism involved is largely unknown. Using the cancer genome atlas (TCGA) data set and bioinformatics analyses, we identified

Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1beta and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis

Olkkonen J, et al.

PLoS ONE, 10(12), e0145279-e0145279 (2015)

DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP