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I3657

Insulin-Like Growth Factor Binding Protein-2 from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

IGFBP-2

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD02099094

Key Documents

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Product Name

Insulin-Like Growth Factor Binding Protein-2 from mouse, ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

biological source

mouse

recombinant

expressed in NSO cells

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

0.125-0.5 mg per mL ED50

mol wt

~35 kDa by SDS-PAGE (reducing)
calculated mol wt 29.4 kDa

packaging

pkg of 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

D3YU40

storage temp.

−20°C

Quality Level

200

Gene Information

mouse ... Igfbp2(16008)

Biochem/physiol Actions

Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

General description

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

Physical form

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK1963
020M1205
099K1464
049K1407
117K1347

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Xinchun Shen et al.
The Journal of biological chemistry, 290(18), 11578-11590 (2015-03-20)
Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase and tensin
Hye Suk Kang et al.
The Biochemical journal, 467(3), 453-460 (2015-02-20)
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In
Gang Xi et al.
Endocrinology, 154(11), 4146-4157 (2013-08-29)
IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains
Gang Xi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)
Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts

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Data Sheet - I3657

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