I3661
Insulin-FITC labeled human
recombinant, expressed in yeast, lyophilized powder
Synonym(s):
FITC Insulin, Labeled Human Insulin
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About This Item
UNSPSC Code:
12352204
EC Number:
234-279-7
NACRES:
NA.83
Form:
lyophilized powder, solid
Recombinant:
expressed in yeast
recombinant
expressed in yeast
form
lyophilized powder, solid
composition
Insulin, ≥75% biuret
extent of labeling
≥1 mol FITC per mol insulin
Quality Level
General description
Insulin is a polypeptide hormone mainly secreted from pancreas when glucose level changes in the plasma. It is an anabolic hormone and enhances the generation of storage substances, for instance glycogen, fat and protein. It also induces glucose uptake by peripheral tissues, thereby controlling glucose levels in the plasma. Its main sites of action are liver, adipose tissue and muscle.
Application
Insulin-FITC labeled human has been used in primary endothelial cells from human adipose tissue microvasculature (HAMEC) to study insulin transcytosis.
Physical form
Lyophilized powder containing sodium phosphate buffer salts
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
wgk
WGK 3
Regulatory Information
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Espinal J
Understanding Insulin Action: Principles and Molecular Mechanisms (1989)
Cristina C Clement et al.
Scientific reports, 8(1), 11253-11253 (2018-07-28)
Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome
Aaron L Glieberman et al.
Lab on a chip, 19(18), 2993-3010 (2019-08-30)
Pancreatic β cell function is compromised in diabetes and is typically assessed by measuring insulin secretion during glucose stimulation. Traditionally, measurement of glucose-stimulated insulin secretion involves manual liquid handling, heterogeneous stimulus delivery, and enzyme-linked immunosorbent assays that require large numbers
Mahmoud S Alghamri et al.
ACS nano, 16(6), 8729-8750 (2022-05-27)
Glioblastoma (GBM) is an aggressive primary brain cancer, with a 5 year survival of ∼5%. Challenges that hamper GBM therapeutic efficacy include (i) tumor heterogeneity, (ii) treatment resistance, (iii) immunosuppressive tumor microenvironment (TME), and (iv) the blood-brain barrier (BBB). The
Hanwoong Woo et al.
Molecular brain, 11(1), 37-37 (2018-07-05)
Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus. However, the relation between chronic stress and insulin signaling at the molecular
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