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I3769

Sigma-Aldrich

Insulin-like Growth Factor-I human

≥95% (HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IGF, IGF-I, somatomedin c

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50 μG
¥1,899.16
100 μG
¥3,074.01

¥1,899.16

Estimated to ship on2025年9月25日Details

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50 μG
¥1,899.16
100 μG
¥3,074.01

About This Item

MDL number:
MFCD00081716
UNSPSC Code:
12352202
NACRES:
NA.77

¥1,899.16

Estimated to ship on2025年9月25日Details

New, lower price on this item!

Product Name

Insulin-like Growth Factor-I human, IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

≥95% (HPLC)

form

lyophilized powder

potency

0.1-10 ng/mL ED50/EC50

quality

endotoxin tested

mol wt

~7.6 kDa

packaging

pkg of 50 and 100 μg

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This Item
SRP3069I4657F5542
Insulin-like Growth Factor-I human IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

I3769

Insulin-like Growth Factor-I human

IGF-I human Animal-component free, recombinant, expressed in E. coli, suitable for cell culture

SRP3069

IGF-I human

Insulin-like Growth Factor-I Receptor human ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

I4657

Insulin-like Growth Factor-I Receptor human

Fibroblast Growth Factor-Acidic human FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture

F5542

Fibroblast Growth Factor-Acidic human

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in E. coli

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

General description

Insulin-like growth factor I (IGF-I) is localized on human chromosome 12q23.2.[1]

Application

Insulin-like Growth Factor-I human has been used:
  • in modified Dulbecco minimal essential medium for in vitro culture of testicular cells[2][3]
  • in culture media, to study its effect on steroidogenesis during testicular development[4]
  • in culture media for in vitro assay of splenic pro-erythroid cell growth and differentiation[5]

Biochem/physiol Actions

IGF-I also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
IGF-I, also known as somatomedin C, mediates the growth-promoting activity of GH (growth hormone). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis. IGF-I exerts its actions through the IGF-I receptor.
Insulin-like growth factor I (IGF-I) plays a critical role in cellular energy metabolism and growth and development, especially prenatal growth.[6]

Physical form

Lyophilized from 0.2 μm filtered solution in 50 mM acetic acid.

Reconstitution

Reconstitute in water

Analysis Note

The biological activiy is calculated by the dose-dependent proliferation of murine BALBC/3T3 cells. ED50 corresponds to a specific activity of at least 1 x 105 units/mg.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

兴奋剂肽类激素
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    Lot/Batch Number
    0000403810
    0000403812
    0000350247
    0000350245
    0000301482

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