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I4276

Interferon-αA human

Name: Interferon-αA human
Brand: SIGMA

≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli

Synonym(s):

IFN-αA, Interferon-α2A

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About This Item

CAS Number:

105388-21-4

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD01635115

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Properties

biological source

human

Quality Segment

200

recombinant

expressed in E. coli

assay

≥95%

form

buffered aqueous solution

mol wt

19 kDa

packaging

pkg of 20 μg

concentration

≥0.2 mg/mL

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

UniProt accession no.

P01563

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IFNA2(3440)

Description

Application

Interferon-αA human has been used to:

study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signalingPMID 20686047
study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replicationPMID 19243496
compare the effect of Monascus pigment derivatives on hepatitis C virus replicationPMID 22076990

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Physical form

Supplied as a solution in 5 mM sodium acetate, pH 4.0.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c