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CN

I4375

Inosine 5′-diphosphate sodium salt

≥96%

Synonym(s):

IDP

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About This Item

Empirical Formula (Hill Notation):
C10H14N4O11P2
CAS Number:
Molecular Weight:
428.19
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥96%
Biological source:
microbial
Form:
powder
Solubility:
water: 50 mg/mL, clear to very slightly hazy, colorless
Storage temp.:
−20°C
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InChI

1S/C10H14N4O11P2.3Na/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)n2cnc3C(=O)NC=Nc23

InChI key

CPIQGMJSIPVOOS-MSQVLRTGSA-K

biological source

microbial

assay

≥96%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

Quality Level

Application

Inosine 5′-diphosphate sodium salt has been used for hystoenzymatic demonstration of nucleoside diphosphatase (NDPase).

Preparation Note

Prepared from muscle or bacterial ADP.

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

STOT SE 2

target_organs

Eyes,Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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John A Duley et al.
Therapeutic drug monitoring, 27(5), 647-654 (2005-09-22)
Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the usefulness of TGNs and other
Satoko Ohkubo et al.
European journal of pharmacology, 577(1-3), 35-43 (2007-09-20)
In C6 glioma cells, adenine nucleotides, especially AMP, and adenosine inhibited cell proliferation in time- and concentration-dependent manners. alpha,beta-methylene-ADP, an ecto-5'-nucleotidase inhibitor, suppressed the hydrolysis of AMP and reversed the inhibition of cell growth induced by AMP but not by
Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice
Lorke DE, et al.
Histochemistry and Cell Biology, 130(4), 693-697 (2008)
Edwin K Jackson et al.
The Journal of pharmacology and experimental therapeutics, 321(2), 799-809 (2007-02-23)
Stimulation of adenylyl cyclase causes cellular efflux of cAMP, and cAMP (unlike adenosine) is stable in blood. Therefore, it is conceivable that cAMP could function as a circulating adenosine prohormone by local target-organ conversion of distally released cAMP to adenosine
CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model
Almolda B, et al.
Journal of Neuroimmunology, 209(1-2), 65-80 (2009)

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