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I5403

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

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Synonym(s):
IGFBP-2
MDL number:
MFCD02099094
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

0.04 μg/mL

mol wt

~36 kDa by SDS-PAGE
calculated mol wt ~31 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P18065

storage temp.

−20°C

Gene Information

human ... IGFBP2(3485)

Related Categories

General description

The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35.

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast.

Physical form

Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319 - H332

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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K M Kelley et al.
The international journal of biochemistry & cell biology, 28(6), 619-637 (1996-06-01)
The IGFBPs are a family of homologous proteins that have co-evolved with the IGFs and that confer upon the IGF regulatory system both functional and tissue specificity. IGFBPs are not merely carrier proteins for IGFs, but hold a central position
Chad P Garner et al.
Human genetics, 123(3), 247-255 (2008-01-23)
The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher
H Yu et al.
Journal of clinical laboratory analysis, 13(4), 166-172 (1999-07-22)
Insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. Clinical and epidemiological studies have indicated that measuring IGFs and IGFBPs in blood has potential implications in assessing growth-related abnormalities and risks
Soo Hyun Park et al.
Investigative ophthalmology & visual science, 56(12), 7293-7302 (2015-11-13)
Previously, we reported that keratocyte-conditioned medium (KCM) facilitates the differentiation of human mesenchymal stem cells (hMSCs) into corneal keratocyte-like cells. This study is designed to investigate the roles of insulin-like growth factor binding protein 2 (IGFBP2) for the regulation of

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