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I6138

Idazoxan hydrochloride

Name: Idazoxan hydrochloride
Brand: SIGMA

α2-adrenoceptor antagonist

Synonym(s):

(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride, RX 781094

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₂N₂O₂ · HCl

CAS Number:

79944-56-2

Molecular Weight:

240.69

UNSPSC Code:

12352200

PubChem Substance ID:

24278493

NACRES:

NA.77

MDL number:

MFCD00069293

Quality level:

100

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Product Name

Idazoxan hydrochloride,

Quality Level

100

solubility

H₂O: 50 mg/mL

SMILES string

Cl.C1CN=C(N1)C2COc3ccccc3O2

InChI

1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H

InChI key

MYUBYOVCLMEAOH-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Related Categories

Bioactive Small Molecules

Application

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

Vidya Narayanaswami et al.

Molecular imaging, 17, 1536012118792317-1536012118792317 (2018-09-12)

The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain's resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury

Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA, or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test

Reneric, J P, et al.

Neuropsychopharmacology, 24(4), 379-379 (2001)

Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.

Valerio Mammoli et al.

Bioorganic & medicinal chemistry, 20(7), 2259-2265 (2012-03-01)

Aim of the present study was to obtain novel α(2)-adrenoreceptor (α(2)-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α(2)-AR antagonist idazoxan, we designed 1,4-dioxane derivatives bearing an aromatic area in position 5 or 6 and the

Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition.

Sidney P Kuo et al.

Neuron, 71(2), 306-318 (2011-07-28)

Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline

Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats.

Christopher J Barnum et al.

Pharmacology, biochemistry, and behavior, 100(3), 607-615 (2011-10-08)

While L-3,4-dihydroxyphenylalanine (L-DOPA) remains the standard treatment for Parkinson's disease (PD), long-term efficacy is often compromised by L-DOPA-induced dyskinesia (LID). Recent research suggests that targeting the noradrenergic (NE) system may provide relief from both PD and LID, however, most PD

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Global Trade Item Number

SKU	GTIN
I6138-50MG	04061832091525
I6138-100MG	04061832091518

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