I6410
ISCK03
≥98% (HPLC), solid
Synonym(s):
Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl], [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
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About This Item
Empirical Formula (Hill Notation):
C19H21N3O2S
CAS Number:
Molecular Weight:
355.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: ≥20 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3
InChI
1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
InChI key
XQABBHBFHWHMKF-UHFFFAOYSA-N
Biochem/physiol Actions
ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner.
ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner. ISCK03 inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells. Complete inhibition was observed with 1 and 5 μM ISCK03.
Features and Benefits
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| I6410-5MG | 04061833219249 |
| I6410-25MG | 04061833219232 |