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Merck
CN

I7160

IMS2186

≥98% (HPLC), solid

Synonym(s):

3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

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About This Item

Empirical Formula (Hill Notation):
C18H16O4
CAS Number:
1031206-36-6
Molecular Weight:
296.32
NACRES:
NA.77
PubChem Substance ID:
329815315
UNSPSC Code:
12352200
MDL number:
MFCD12912419

Key Documents

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InChI key

BZCADTHMZLYKAR-MDWZMJQESA-N

SMILES string

COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O

InChI

1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
IMS2186 is an anti-proliferative and anti-angiogenic.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000448059
0000448059
128K4612V
128K4612

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