I7378
Indomethacin
98.5-100.5% (in accordance with EP)
biological source
synthetic
Quality Level
Assay
98.5-100.5% (in accordance with EP)
form
powder or crystals
loss
≤0.5% loss on drying
mp
158-162 °C
Mode of action
enzyme | inhibits
SMILES string
COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
InChI
1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key
CGIGDMFJXJATDK-UHFFFAOYSA-N
Gene Information
human ... ALB(213) , ALOX5(240) , ELA2(1991) , GPR44(11251) , IL1A(3552) , PLA2G1B(5319) , PTGDR(5729) , PTGS1(5742) , PTGS2(5743)
mouse ... Alox5(11689) , Ptgdr(19214) , Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219) , Ptgs1(19224)
rat ... Alox5(25290) , Ptgs1(24693) , Ptgs2(29527)
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General description
Application
- as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
- as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
- in the inhibition of prostaglandin E2 (PGE2) in T cells
Biochem/physiol Actions
Features and Benefits
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral
Storage Class Code
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
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