Skip to Content
Merck
CN

Key Documents

View All Documentation

I7379

Imipramine hydrochloride

≥99% (TLC), powder, selective serotonin reuptake inhibitor

Synonym(s):

10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C19H24N2 · HCl
CAS Number:
113-52-0
Molecular Weight:
316.87
NACRES:
NA.77
PubChem Substance ID:
24278097
UNSPSC Code:
12352116
EC Number:
204-030-7
MDL number:
MFCD00012669
Assay:
≥99% (TLC)
Form:
powder
Quality level:
200
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Imipramine hydrochloride, ≥99% (TLC)

Quality Level

200

assay

≥99% (TLC)

form

powder

color

white

solubility

H2O: 50 mg/mL

originator

Novartis

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChI key

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A2(6530), SLC6A4(6532)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

Application

Imipramine hydrochloride has been used:
  • as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
  • to investigate its interaction with insulin in aqueous solution
  • to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM).
Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000503901
0000503901
0000481757
0000481757
0000450307

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Psychotropic drugs
Drugs During Pregnancy and Lactation, 743-774 (2015)
Attention Deficit Hyperactivity Disorder
Comprehensive Medicinal Chemistry II.: Global perspective (2007)
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
Willnow TE, et al.
Test, 267(36), 26172-26180 (1992)
Thermodynamic study of the imipramine-insulin interaction
Lopez-Fontan J, et al.
The Journal of Chemical Thermodynamics, 31(10), 1297-1306 (1999)
Direct retino-raphe projection alters serotonergic tone and affective behavior
Ren C, et al.
Neuropsychopharmacology, 38(7), 1163-1163 (2013)
View All Related Papers

Global Trade Item Number

SKUGTIN
I7379-100G04061833858202
I7379-25G04061832091556
I7379-5G04061833858219

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service