Monoclonal Anti-Interleukin-1α antibody produced in mouse

purified, E. coli-derived recombinant human interleukin-1α.

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signaling through IL-1 receptor type 1. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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