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I8021

L-N6-(1-Iminoethyl)lysine dihydrochloride

Synonym(s):

L-Lysine ω-acetamidine dihydrochloride, L-NIL dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H17N3O2 · 2 HCl
CAS Number:
159190-45-1
Molecular Weight:
260.16
NACRES:
NA.77
PubChem Substance ID:
24278827
UNSPSC Code:
12352209
MDL number:
MFCD00270890
Assay:
≥97% (HPLC)
Form:
powder
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biological source

synthetic (organic)

assay

≥97% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O

InChI

1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1

InChI key

OQIBCXRAFAHXMM-KLXURFKVSA-N

Gene Information

human ... NOS2(4843)

Application

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
  • to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
  • to study its effects on leptin-induced inflammation in hepatocytes
  • to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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