I8026
Anti-Interleukin-8 antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-CXCL8, Anti-IL-8
Product Name
Anti-Interleukin-8 antibody produced in goat, affinity isolated antibody, lyophilized powder
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunocytochemistry: 5-15 μg/mL
immunohistochemistry: 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... IL8(3576)
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Application
Anti-Interleukin-8 antibody can be used for the following :
- For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8.
- Immunoblotting.
- ELISA.
Anti-Interleukin-8 antibody can be used in immunocytochemistry and immunohistochemistry.
Biochem/physiol Actions
Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis.
The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3.
Immunogen
recombinant human IL-8 (CXCL8).
Physical form
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
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Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach.
Ruff A L, et al.
Archives of Toxicology, 90(2), 375-383 (2016)
Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria.
Kasperska-Zajac A, et al.
Journal of Biological Regulators and Homeostatic Agents, 31(4), 957-961 (2017)
Properties of pro-inflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF).
N Mukaida et al.
Microbiology and immunology, 36(8), 773-789 (1992-01-01)
T Yoshimura et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(24), 9233-9237 (1987-12-01)
Stimulated human monocytes release several proteins thought to play a role in inflammation, including interleukin 1, tumor necrosis factor, and plasminogen activator. We have purified another proinflammatory protein that is chemotactic for human neutrophils from conditioned medium of lipopolysaccharide-stimulated monocytes.
Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8.
Ji S, et al.
Oncotarget, 7(31), 49411-49411 (2016)
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Instructions
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