I8529
Insulin-like Growth Factor Binding Protein-5 human
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
IGFBP-5
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About This Item
biological source
human
Quality Segment
recombinant
expressed in NSO cells
assay
>90% (SDS-PAGE)
form
lyophilized powder
potency
0.5-1.5 mg per mL ED50
mol wt
34 kDa by SDS-PAGE (reducing), calculated mol wt ~28 kDa
packaging
pkg of 25 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IGFBP5(3488)
General description
The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.
Biochem/physiol Actions
Binds to bone cells and is the predominant insulin-like growth factor binding protein in bone; when binding the extracellular matrix, it modulates IGF activity.
IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.
Analysis Note
The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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