I9032
Interferon β from mouse
≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Synonym(s):
IFN β
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¥3,142.90
List Price¥4,489.86Save 30%In StockDetails
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This Item | I8782 | I8907 | I8657 |
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in CHO cells | recombinant expressed in bacteria |
| assay ≥95% | assay ≥95% | assay ≥95% | assay ≥95% |
| biological source mouse | biological source mouse | biological source rat | biological source rat |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form buffered aqueous solution | form buffered aqueous solution | form lyophilized powder | form lyophilized powder |
General description
IFN β (interferon β) is from the type 1 interferon family of cytokines.[1]
Interferon β (IFN-β) possesses a signal peptide region. It has comparatively more hydrophobic residues and displays 30% homology with IFN-α.[2]
The gene encoding interferon β (Infb1) is localized on mouse chromosome 4.[3]
Application
Interferon β from mouse has been used:
- in the stimulation of bone marrow-derived dendritic cells (BMDCs)[4]
- as a cytokine to stimulate differentiation of podocytes[5]
- to stimulate splenocytes[6]
Interferon ß from mouse has been used:
- to induce the activation of cholesterol 25-hydroxylase, by in vitro stimulation of bone marrow-derived macrophages, dendritic cells and CD11c+ lung macrophages[4]
- to stimulate splenocytes, in order to study the secretion and regulation of IFN-γ [7]
- to intranasally pre-treat neonatal mice, to study its effects on the protective actions of Lactobacillus rhamnosus GG (LGG)[8]
- as a standard to treat MEF-Mx2-luc-BKO reporter cell line for IFN-β measurement, in response to human adenovirus-5 (HAdV-C5)[9]
Biochem/physiol Actions
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response.[10] It is also important for anti-inflammatory effects.[1]
Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α).[11] It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor.[11] IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression.[11] It has therapeutic potential in treating rheumatoid arthritis[11] and relapsing-remitting multiple sclerosis (MS).[12]
Physical form
Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.
Analysis Note
The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
含少量动物源组分生物产品
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Vasco Marcato et al.
Molecular and cellular biology, 36(1), 13-29 (2015-10-16)
Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been associated with the constitutive production of IFN-β in
Patrick Ejlerskov et al.
Cell, 163(2), 324-339 (2015-10-10)
Neurodegenerative diseases have been linked to inflammation, but whether altered immunomodulation plays a causative role in neurodegeneration is not clear. We show that lack of cytokine interferon-β (IFN-β) signaling causes spontaneous neurodegeneration in the absence of neurodegenerative disease-causing mutant proteins.
Judith van Holten et al.
Arthritis research & therapy, 6(3), R239-R249 (2004-05-15)
We investigated the therapeutic potential and mechanism of action of IFN-beta protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections of recombinant
Leesa M Pennell et al.
Immunology, 152(3), 439-450 (2017-06-25)
CD11c+ dendritic cells (DCs) exert a critical role as antigen-presenting cells in regulating pathogenic T cells in multiple sclerosis (MS). To determine whether the therapeutic benefit of interferon-β (IFN-β) treatment for MS is in part influenced by IFN regulation of
ENU-induced mutation in USP18 causes hyperactivation of IFN-alphabeta signalling and suppresses STAT4-induced IFN-gamma production resulting in increased susceptibility to Salmonella Typhimurium
Richer E, et al.
Journal of immunology (Baltimore, Md. : 1950), 185(6), 3593-3593 (2010)
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