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Merck
CN

I9404

Interleukin-10/Fc Chimera (non-lytic) human

>98% (SDS-PAGE), recombinant, expressed in NS.1 cells, buffered aqueous solution

Synonym(s):

IL-10:Fc (non-lytic) human

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
Form:
buffered aqueous solution
Assay:
>98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NS.1 cells
Mol wt:
98 kDa
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biological source

human

Quality Segment

recombinant

expressed in NS.1 cells

assay

>98% (SDS-PAGE)

form

buffered aqueous solution

mol wt

98 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL10(3586)

General description

The gene IL-10 (interleukin-10) is mapped to human chromosome 1q31-32. It is secreted by monocytes and lymphocytes.

Biochem/physiol Actions

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.
Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Other Notes

Dimeric fusion protein consisting of human IL-10 fused to mutant human IgG1 Fc.


Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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