I9646
IL-6 mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
Interleukin-6, mIL-6, IL-6
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About This Item
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
~21.7 kDa
Impurities:
≤1.000 EU/mg Endotoxin level
Product Name
Interleukin-6 from mouse, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free
biological source
mouse
Quality Segment
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
0.02-0.2 ng/mL EC50
quality
endotoxin tested
mol wt
~21.7 kDa
packaging
pkg of 5 and 25 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/mg Endotoxin level
color
white
UniProt accession no.
storage temp.
−20°C
General description
Recombinant mouse Interleukin‑6 (IL‑6) is a multifunctional cytokine expressed in E. coli and supplied as a carrier‑free lyophilized powder. IL‑6 is widely used in mammalian cell culture research involving immune and inflammatory signaling pathways in vitro.
Application
Recombinant mouse IL‑6 has been used in mammalian cell culture research applications, including immune cell proliferation assays and cytokine‑mediated signaling studies in vitro.
Biochem/physiol Actions
Interleukin‑6 (IL‑6) is an immunomodulatory cytokine that supports proliferation and differentiation of multiple cell types. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 is involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response.
Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
Physical form
Lyophilized from a sterile filtered solution with no additives.
Analysis Note
The biological activity of recombinant mouse IL-6 was measured in a cell proliferation assay using T1165.85.2.1 cells.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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