J2128
Anti-phospho-c-Jun (pSer63) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, FACS, WB CL
Citations:
7
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen 48 kDa
species reactivity
rat, mouse, human
technique(s)
flow cytometry: 1:200, microarray: suitable, western blot (chemiluminescent): 1:1,000 using extract of NIH3T3 anisomycin or UV-treated cells
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer63)
Gene Information
human ... JUN(3725)
mouse ... Jun(16476)
Immunogen
synthetic phosphoserine63 peptide corresponding to residues around Ser63 of human c-Jun, conjugated to KLH.
Application
Anti-phospho-c-Jun (pSer63) antibody produced in rabbit has been used in microarray analysis to identify the changes in the level of cellular proteins in cells inoculated with Equine influenza virus.
Biochem/physiol Actions
The antibody does not react with the corresponding phosphorylated form of JunD or JunB.
The protooncogene c-Jun encodes a member of the jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes.
Physical form
Solution in 10 mM HEPES sodium, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and 50% glycerol.
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Storage Class
10 - Combustible liquids
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