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J3770

JNJ7777120

Name: JNJ7777120
Brand: SIGMA

≥98% (HPLC), histamine receptor antagonist, solid

Synonym(s):

1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₆N₃OCl

CAS Number:

459168-41-3

Molecular Weight:

277.75

UNSPSC Code:

12352200

PubChem Substance ID:

329815408

NACRES:

NA.77

MDL number:

MFCD04343337

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Product Name

JNJ7777120, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2

InChI

1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3

InChI key

HUQJRYMLJBBEDO-UHFFFAOYSA-N

Description

Application

JNJ7777120 has been used as a histamine-4 receptor antagonist:

to study its effects on the pro-inflammatory microglia in rats
to study its effects on the Parkinson′s-like pathology in rat brain
to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)

Biochem/physiol Actions

JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.

JNJ7777120 is a potent, selective non-imidazole H₄ histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)