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Merck
CN

K0890

Anti-Potassium Channel Kv11.3 (erg3) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-KCNH7, Anti-ether-a-go-go-related channel 3

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Potassium Channel Kv11.3 (erg3) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable using rat brain sections
western blot: 1:300 using rat brain lysates

UniProt accession no.

Q9NS40

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... KCNH7(90134)
mouse ... Kcnh7(170738)
rat ... Kcnh7(170739)

Biochem/physiol Actions

The KV11.3 antibody is directed against an intracellular epitope of C-terminal part of KV11.3.
The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K+ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K+ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.

General description

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K+ channels. The erg K+ channels are part of the EAG (ether-à-go-go) family of voltage-gated K+ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.

Immunogen

synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat KV11.3.

Physical form

Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.

Preparation Note

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

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Storage Class

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
077K1375
077K1369

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Functional properties of human neuronal Kv11 channels.
Einarsen K
Pflugers Archiv : European Journal of Physiology, 458, 689-700 (2009)
Sönke Cordeiro et al.
PloS one, 6(12), e29490-e29490 (2011-12-30)
In response to light, most retinal neurons exhibit gradual changes in membrane potential. Therefore K+ channels that mediate threshold currents are well-suited for the fine-tuning of signal transduction. In the present study we demonstrate the expression of the different Kv11

Related Content

Data Sheet - K0890

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