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K1388

KT5823

Name: KT5823
Brand: SIGMA

≥85% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₂₅N₃O₅

CAS Number:

126643-37-6

Molecular Weight:

495.53

UNSPSC Code:

12352200

PubChem Substance ID:

24896206

NACRES:

NA.77

MDL number:

MFCD09878278

Assay:

≥85% (HPLC)

Form:

lyophilized powder

Quality level:

100

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Product Name

KT 5823, ≥85% (HPLC), lyophilized powder

Quality Level

100

assay

≥85% (HPLC)

form

lyophilized powder

color

white

solubility

ethyl acetate: 5 mg/mL

storage temp.

2-8°C

SMILES string

COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC

InChI

1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1

InChI key

QTYMDECKVKSGSM-YMUMJAELSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

General description

KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na⁺/I⁻ symporter (NIS) expression.

Application

KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.

Biochem/physiol Actions

Selective inhibitor of PKG.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Atrial Natriuretic Peptide Promotes Neurite Outgrowth and Survival of Cochlear Spiral Ganglion Neurons in vitro Through NPR-A/cGMP/PKG Signaling.

Fei Sun et al.

Frontiers in cell and developmental biology, 9, 681421-681421 (2021-07-17)

Sensorineural hearing loss (SNHL) is a dominant public health issue affecting millions of people around the globe, which is correlated with the irreversible deterioration of the hair cells and spiral ganglion neurons (SGNs) within the cochlea. Strategies using bioactive molecules

Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling?

Junhui Sun et al.

Free radical biology & medicine, 54, 105-112 (2012-09-20)

Nitric oxide (NO) plays an important role in acute ischemic preconditioning (IPC). In addition to activating soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) signaling pathways, NO-mediated protein S-nitros(yl)ation (SNO) has been recently shown to play an essential

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.

Harraz OF, et al.

eLife, 7(6), e38689-e38689 (2018)

KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.

Burkhardt M, et al.

The Journal of Biological Chemistry, 275(43), 33536-33541 (2000)

Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

Sandra S Mizokami et al.

Journal of natural products, 75(5), 896-904 (2012-05-12)

Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants including Sphagneticola trilobata. The only documented evidence for its antinociceptive effect is that it inhibits the writhing response induced by acetic acid in mice. Therefore, the analgesic effect

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Global Trade Item Number

SKU	GTIN
K1388-100UG	04061833867976

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