K1519
KM11060
≥98% (HPLC)
Synonym(s):
7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
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About This Item
Empirical Formula (Hill Notation):
C19H17Cl2N3O2S
CAS Number:
Molecular Weight:
422.33
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL
storage temp.
room temp
SMILES string
Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccnc4cc(Cl)ccc34
InChI
1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
InChI key
GIEHIZKCIZLXLF-UHFFFAOYSA-N
Biochem/physiol Actions
KM11060 is a mutated F508del CFTR corrector.
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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