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K1639

K-252a

Name: K-252a
Brand: SIGMA

from Nonomuraea longicatena, ≥98% (HPLC)

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₁N₃O₅

CAS Number:

99533-80-9

Molecular Weight:

467.47

NACRES:

NA.77

PubChem Substance ID:

24896210

UNSPSC Code:

12352200

MDL number:

MFCD00161522

Assay:

≥98% (HPLC)

Form:

solid

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Properties

biological source

Nonomuraea longicatena

Quality Segment

200

assay

≥98% (HPLC)

form

solid

solubility

DMF: 1 mg/mL, DMSO: 1 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

Gene Information

human ... NTRK1(4914)
rat ... Prkca(24680)

Description

Application

K-252a has been used:

as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly

Biochem/physiol Actions

K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC₅₀ values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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