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Merck
CN

K3269

Anti-Kindlin-2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FERMT2, Anti-Fermitin family homolog 2, Anti-KIND2, Anti-MIG2, Anti-Mitogen inducible gene 2 protein, Anti-PLEKHC1, Anti-Pleckstrin homology domain containing, family C member 1, Anti-UNC112, Anti-UNC112B

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Kindlin-2 antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~72 kDa

species reactivity

mouse, rat, canine, human

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells
western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells

UniProt accession no.

Q96AC1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... FERMT2(10979)
mouse ... Fermt2(218952)
rat ... Fermt2(289992)

Application

Anti-kindlin-2 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Kindlin-2 acts as a focal adhesion protein and controls breast cancer progression by promoting genome instability. Kindlin-2, as an integrin-interacting protein, plays a vital role in integrin activation and integrin-mediated cell-extracellular matrix (ECM) interaction. Kindlin-2 expression is associated with poor prognosis of patients with hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinomas (PDACs). Therefore, kindlin-2 can be considered as a potential biomarker for patients with HCC and PDACs.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-kindlin-2 recognizes human, mouse, rat and canine kindlin-2. Kindlin-2, also known as fermitin family member 2 (FERMT2) or pleckstrin homology domain-containing family C member 1 (PLEKHC1), is encoded by the gene mapped to human chromosome 14q22.1. Kindlin-2 is a member of the kindlin protein family and has a ubiquitous expression pattern.

Other Notes

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000490137
0000490137
0000430839
0000430839
0000364960

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Bing Li et al.
Science China. Life sciences, 62(2), 225-234 (2018-11-22)
Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary
Xiaowei Xue et al.
Cancer medicine, 9(14), 4971-4979 (2020-05-22)
Breast cancer was the most frequent and the second most deadly cancer in women in 2018 in China; thus, early diagnosis of breast cancer is important. Studies have reported that tissue stiffness promotes cancer progression through increased collagen or fibrosis.
Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling
Wu X, et al.
International Journal of Molecular Medicine, 37, 436-444 (2016)
Ting Zhao et al.
Cancer letters, 330(2), 208-216 (2012-12-06)
Kindlin-2, as a focal adhesion protein, has been found to regulate tumor progression. However, the mechanism underlying Kindlin-2 regulation of tumor progression is largely unknown. Here, we report that Kindlin-2 regulates breast cancer cell proliferation, apoptosis and chromosomal abnormalities in
Prawej Mahawithitwong et al.
Pancreas, 42(4), 663-669 (2013-03-20)
Kindlin-2 is a novel focal adhesion protein reported to be expressed in breast, lung, and gastric cancers. This study aimed to investigate the significance of kindlin-2 expression in pancreatic ductal adenocarcinomas (PDACs). We performed immunohistochemical analysis on kindlin-2 on PDAC
View All Related Papers

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Data Sheet - K3269

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