K3643
PKAcγ, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
KAPG, PKAr, cAPKr
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
128-174 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
128-174 nmol/min·mg
mol wt
~65 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... PRKACG(5568)
Biochem/physiol Actions
PKAcγ (protein kinase cAMP-activated catalytic subunit γ) is a catalytic isoform of cyclic adenosine monophosphate-dependent protein kinase. It is an intronless gene and has a testis-specific expression. It is involved in platelet biogenesis. Mutation in PKAcγ causes macrothrombocytopenia, an inherited thrombocytopenias.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Vladimir T Manchev et al.
Blood, 124(16), 2554-2563 (2014-07-26)
Macrothrombocytopenias are the most important subgroup of inherited thrombocytopenias. This subgroup is particularly heterogeneous because the affected genes are involved in various functions such as cell signaling, cytoskeleton organization, and gene expression. Herein we describe the clinical and hematological features
S J Beebe et al.
Molecular endocrinology (Baltimore, Md.), 4(3), 465-475 (1990-03-01)
Two different mammalian genes for the catalytic subunit (C) of cAMP-dependent protein kinase have previously been characterized (C alpha, C beta). In the present study, we report the molecular cloning of a third isoform of C, from a human testis
N Reinton et al.
Genomics, 49(2), 290-297 (1998-05-23)
Three different catalytic isoforms of cAMP-dependent protein kinase have been identified (C alpha, C beta, and C gamma). We report the cloning and characterization of the human and rhesus monkey genes encoding the testis-specific C gamma subunit. The human C
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