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About This Item
Empirical Formula (Hill Notation):
C13H15N3O2S
CAS Number:
Molecular Weight:
277.34
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
InChI
1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
InChI key
JEFVYQYZCAVNTP-UHFFFAOYSA-N
Biochem/physiol Actions
A thiadiazoline derivative reported as a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor.
Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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