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K3761

KT 5720

Name: KT 5720
Brand: SIGMA

From microbial, ≥98% (HPLC), PKA inhibitor, powder

Synonym(s):

(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester

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About This Item

Empirical Formula (Hill Notation):

C₃₂H₃₁N₃O₅

CAS Number:

108068-98-0

Molecular Weight:

537.61

UNSPSC Code:

51111800

PubChem Substance ID:

24896235

NACRES:

NA.77

MDL number:

MFCD00132118

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Product Name

KT 5720, ≥98% (HPLC), powder

biological source

microbial

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to faint yellow

solubility

methanol: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1

InChI key

ZHEHVZXPFVXKEY-IKZDWWSZSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

Biochem/physiol Actions

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000461909

0000310521

0000285471

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Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer

Luo H, et al.

Journal of Experimental & Clinical Cancer Research, 30(1), 6-6 (2011)

Calcium and cAMP levels interact to determine attraction versus repulsion in axon guidance.

Elizabeth M Forbes et al.

Neuron, 74(3), 490-503 (2012-05-15)

Correct guidance of axons to their targets depends on an intricate network of signaling molecules in the growth cone. Calcium and cAMP are two key regulators of whether axons are attracted or repelled by molecular gradients, but how these molecules

'Silent' priming of translation-dependent LTP by ß-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors.

Gustavo Tenorio et al.

Learning & memory (Cold Spring Harbor, N.Y.), 17(12), 627-638 (2010-11-26)

The capacity for long-term changes in synaptic efficacy can be altered by prior synaptic activity, a process known as "metaplasticity." Activation of receptors for modulatory neurotransmitters can trigger downstream signaling cascades that persist beyond initial receptor activation and may thus

Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line

Ishida E, et al.

PLoS ONE, 7(12), e50918-e50918 (2012)

14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing.

Patricia T Yam et al.

Neuron, 76(4), 735-749 (2012-11-28)

Axons must switch responsiveness to guidance cues during development for correct pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons ventrally toward the floorplate. We show that after crossing the floorplate, commissural axons switch their response to Shh from attraction

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Global Trade Item Number

SKU	GTIN
K3761-.1MG	04061833943670

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