L0664
Loxoprofen
solid
Synonym(s):
α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid, Koloxo
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About This Item
Empirical Formula (Hill Notation):
C15H18O3
CAS Number:
Molecular Weight:
246.30
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
form
solid
Quality Level
originator
Daiichi-Sankyo
SMILES string
CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1
InChI
1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)
InChI key
YMBXTVYHTMGZDW-UHFFFAOYSA-N
Gene Information
human ... PTGS1(5742), PTGS2(5743)
Application
Anti-inflammatory; analgesic
Features and Benefits
This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Misato Hashizume et al.
Modern rheumatology, 20(5), 432-438 (2010-04-22)
We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study
M Sugimoto et al.
Biochemical pharmacology, 42(12), 2363-2368 (1991-11-27)
The effect of loxoprofen-Na, a novel non-steroidal anti-inflammatory drug with a prodrug property, on prostaglandin (PG) levels in the inflammatory tissue was investigated with a carrageenin-induced pleurisy model in rats. The intrapleural injection of carrageenin caused a marked increase in
Yasushi Kuribayashi et al.
The journal of obstetrics and gynaecology research, 43(9), 1465-1471 (2017-07-15)
We aimed to determine the frequency of endometrial cancer in infertile women undergoing hysteroscopic endometrial polypectomy for endometrial polyps. A total of 1035 infertile patients who underwent office-based hysteroscopic polypectomy at Sugiyama Clinic Marunouchi between July 2011 and October 2015
C Sakamoto et al.
Alimentary pharmacology & therapeutics, 37(3), 346-354 (2012-12-12)
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed globally, their chronic use increases the risk of upper gastrointestinal (GI) damage. Cyclooxygenase-2-selective NSAIDs are considered to reduce this risk. Current guidelines in Japan recommend loxoprofen sodium (loxoprofen), a pro-drug in the
Mototsugu Kato et al.
Journal of gastroenterology and hepatology, 25(10), 1631-1635 (2010-10-01)
The concomitant use of non-steroidal anti-inflammatory drugs is a risk factor for low-dose aspirin (LDA)-associated upper gastrointestinal toxicity. Lafutidine is an H2-receptor antagonist with gastroprotective activity, produced by acting on capsaicin-sensitive afferent neurons. To evaluate the preventive effect of lafutidine
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