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Merck
CN

L0669

Monoclonal Anti-Leukemia Inhibitory Factor antibody produced in mouse

clone 9824, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-CDF, Anti-Cholinergic differentiation factor, Anti-HILDA, Anti-LIF

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About This Item

NACRES:
NA.41
UNSPSC Code:
51111800

Key Documents

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Product Name

Monoclonal Anti-Leukemia Inhibitory Factor antibody produced in mouse, clone 9824, purified immunoglobulin, lyophilized powder

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9824, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

capture ELISA: 2-4 μg/mL
immunohistochemistry: 25 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL

UniProt accession no.

P15018

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... LIF(3976)

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Biochem/physiol Actions

Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL-6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-c Fos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic cell differentiation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

purified, E. coli-derived recombinant human leukemia inhibitory factor.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCF7231
098K0556

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Xi Cheng et al.
Reproductive biology and endocrinology : RB&E, 15(1), 42-42 (2017-06-05)
A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect
D J Hilton
Trends in biochemical sciences, 17(2), 72-76 (1992-02-01)
Leukaemia inhibitory factor (LIF) is one of a growing number of cytokines that cannot be readily categorized according to its functions. Rather, these pleiotropic hormones have diverse and often overlapping effects on a multitude of cell types: for example, LIF
Marie-Emmanuelle Mathieu et al.
Stem cell reviews, 8(1), 1-15 (2011-05-04)
LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation
S M Metcalfe
Genes and immunity, 12(3), 157-168 (2011-03-04)
At the heart of lineage commitment within the adaptive immune response is the intrinsic genetic plasticity of the naive peripheral T lymphocyte (T cell). Primary activation by presentation of cognate antigen is coupled to rapid T-cell cycling and progressive epigenetic

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Data Sheet - L0669

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