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L0879

Leu-Leu-Leu

Name: Leu-Leu-Leu
Brand: SIGMA

≥90% (elemental analysis), suitable for mass spectrometry (MS)

Synonym(s):

Trileucine

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₃₅N₃O₄

CAS Number:

10329-75-6

Molecular Weight:

357.49

UNSPSC Code:

12352202

PubChem Substance ID:

24896267

NACRES:

NA.26

MDL number:

MFCD00038309

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Properties

Product Name

Leu-Leu-Leu, ≥90% (elemental analysis)

Quality Level

200

assay

≥90% (elemental analysis)

form

powder

technique(s)

electron microscopy: suitable, mass spectrometry (MS): suitable

color

white

storage temp.

−20°C

SMILES string

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

InChI key

DNDWZFHLZVYOGF-UHFFFAOYSA-N

Description

Application

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

动植物源性产品

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Distinct mechanisms of membrane permeation induced by two polymalic acid copolymers.

Hui Ding et al.

Biomaterials, 34(1), 217-225 (2012-10-16)

Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as

Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].

Hui Ding et al.

Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18143-18148 (2010-10-06)

Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cells with drug release into

Investigation of the adsorption mechanism of a peptide in reversed phase liquid chromatography, from pH controlled and uncontrolled solutions.

Anna Andrzejewska et al.

Journal of chromatography. A, 1216(18), 3992-4004 (2009-03-31)

The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorption on a C(12) packing material from an aqueous solution of

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Global Trade Item Number

SKU	GTIN
L0879-1G	04061826691519
L0879-500MG	04061833271957