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L0879

Leu-Leu-Leu

Name: Leu-Leu-Leu
Brand: SIGMA

≥90% (elemental analysis), suitable for mass spectrometry (MS)

Synonym(s):

Trileucine

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₃₅N₃O₄

CAS Number:

10329-75-6

Molecular Weight:

357.49

UNSPSC Code:

12352202

PubChem Substance ID:

24896267

NACRES:

NA.26

MDL number:

MFCD00038309

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Properties

Product Name

Leu-Leu-Leu, ≥90% (elemental analysis)

Quality Level

200

assay

≥90% (elemental analysis)

form

powder

technique(s)

electron microscopy: suitable, mass spectrometry (MS): suitable

color

white

storage temp.

−20°C

SMILES string

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

InChI key

DNDWZFHLZVYOGF-UHFFFAOYSA-N

Description

Application

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

动植物源性产品

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Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90.

M Conconi et al.

The Biochemical journal, 333 ( Pt 2), 407-415 (1998-07-11)

Heat-shock protein 90 (Hsp 90) has been implicated in both protection against oxidative inactivation and inhibition of the multicatalytic proteinase (MCP, also known as 20 S proteasome). We report here that the protective and inhibitory effects of Hsp 90 depend

Trileucine improves aerosol performance and stability of spray-dried powders for inhalation.

David Lechuga-Ballesteros et al.

Journal of pharmaceutical sciences, 97(1), 287-302 (2007-09-08)

For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge

Importance of NF-kappaB in rheumatoid synovial tissues: in situ NF-kappaB expression and in vitro study using cultured synovial cells.

S Yamasaki et al.

Annals of the rheumatic diseases, 60(7), 678-684 (2001-06-19)

To examine whether inhibition of NF-kappaB induces apoptosis of human synovial cells stimulated by tumour necrosis factor alpha (TNFalpha), interleukin 1beta (IL1beta), and anti-Fas monoclonal antibody (mAb). The expression of proliferating cell nuclear antigen (PCNA), NF-kappaB, and the presence of

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Global Trade Item Number

SKU	GTIN
L0879-1G	04061826691519
L0879-500MG	04061833271957