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Merck
CN

L0879

Leu-Leu-Leu

≥90% (elemental analysis), suitable for mass spectrometry (MS)

Synonym(s):

Trileucine

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About This Item

Empirical Formula (Hill Notation):
C18H35N3O4
CAS Number:
10329-75-6
Molecular Weight:
357.49
UNSPSC Code:
12352202
PubChem Substance ID:
24896267
NACRES:
NA.26
MDL number:
MFCD00038309

Key Documents

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Product Name

Leu-Leu-Leu, ≥90% (elemental analysis)

SMILES string

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

InChI key

DNDWZFHLZVYOGF-UHFFFAOYSA-N

assay

≥90% (elemental analysis)

form

powder

technique(s)

electron microscopy: suitable, mass spectrometry (MS): suitable

color

white

storage temp.

−20°C

Quality Level

200

Related Categories

Application

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

动植物源性产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4812
BCCL3876
BCCG6451
BCCC5080
BCBV1900

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K L Strauch et al.
Journal of bacteriology, 156(2), 743-751 (1983-11-01)
Pseudorevertants able to use L-leucyl-L-leucyl-L-leucine as a leucine source have been isolated from a Salmonella typhimurium strain carrying stable (nonreverting) mutations in pepN, pepA, and pepB. These strains carry mutations at a locus pto (peptidase T overproducer) tightly linked to
S A Adibi et al.
Metabolism: clinical and experimental, 32(2), 103-105 (1983-02-01)
When baboons, while consuming an adequate diet, were infused continuously for 3 days with parenteral solutions (1I/day) containing either triglycine (50 mM) or trileucine (5 mM) there was either no or very little accumulation of these peptides either in plasma
David Lechuga-Ballesteros et al.
Journal of pharmaceutical sciences, 97(1), 287-302 (2007-09-08)
For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge
S Yamasaki et al.
Annals of the rheumatic diseases, 60(7), 678-684 (2001-06-19)
To examine whether inhibition of NF-kappaB induces apoptosis of human synovial cells stimulated by tumour necrosis factor alpha (TNFalpha), interleukin 1beta (IL1beta), and anti-Fas monoclonal antibody (mAb). The expression of proliferating cell nuclear antigen (PCNA), NF-kappaB, and the presence of
M Conconi et al.
The Biochemical journal, 333 ( Pt 2), 407-415 (1998-07-11)
Heat-shock protein 90 (Hsp 90) has been implicated in both protection against oxidative inactivation and inhibition of the multicatalytic proteinase (MCP, also known as 20 S proteasome). We report here that the protective and inhibitory effects of Hsp 90 depend
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