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L1011

Labetalol hydrochloride

Name: Labetalol hydrochloride
Brand: SIGMA

>98% (TLC), Competitive β-adrenoceptor antagonist., powder

Synonym(s):

2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₄N₂O₃ · HCl

CAS Number:

32780-64-6

Molecular Weight:

364.87

NACRES:

NA.77

PubChem Substance ID:

24278510

UNSPSC Code:

12352200

EC Number:

251-211-1

MDL number:

MFCD00057663

Assay:

>98% (TLC)

Form:

powder

Quality level:

200

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Product Name

Labetalol hydrochloride, >98% (TLC), powder

Quality Level

200

assay

>98% (TLC)

form

powder

color

white

originator

Schering Plough

SMILES string

Cl.CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(N)=O

InChI

1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H

InChI key

WQVZLXWQESQGIF-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

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Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Competitive β-adrenoceptor antagonist.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08

signalword

Warning

hcodes

H361f

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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The alpha- and beta-adrenoceptor blocking activities of labetalol and its RR-SR (50:50) stereoisomers.

E Riva et al.

British journal of pharmacology, 104(4), 823-828 (1991-12-01)

1. We compared the alpha 1-, alpha 2- and beta 1-adrenoceptor blocking potencies of labetalol with those of its two stereoisomers (RR and SR) in pithed rats and in homogenized rat cerebral cortex and heart. 2. In pithed rats, labetalol

Effects of two antihypertensive agents, labetalol and metoprolol, on the production of reactive oxygen species by normal polymorphonuclear leukocytes in vitro.

R Jaboureck-Bouttier et al.

Hypertension in pregnancy, 18(3), 239-247 (1999-12-10)

Increased lipid peroxidation is a putative causal factor for preeclampsia. Because oxygen free radicals are involved in inducing the lipid oxidation chain reaction, we evaluated two beta adrenoreceptor blockers, labetalol and metoprolol, currently used for treating hypertension with regard to

Acute hypertension promotes hemorrhagic transformation in a rabbit embolic stroke model: effect of labetalol.

S C Fagan et al.

Experimental neurology, 150(1), 153-158 (1998-03-26)

We examined the relationship between acute hypertension following cerebral embolization and subsequent hemorrhagic transformation (HT) in a rabbit embolic stroke model. We have shown previously that the likelihood and severity of hemorrhage were significantly correlated with the magnitude of an

Magnetic nanocomposite-based SELDI probe for extraction and detection of drugs, amino acids and fatty acids.

Mohamed O Amin et al.

Mikrochimica acta, 186(8), 503-503 (2019-07-05)

The use of carbon black-Fe3O4 magnetic nanocomposite (CB-Fe3O4) as a probe for surface-enhanced laser desorption ionization mass spectrometry (SELDI-MS) with a high extraction efficiency and sensitive detection is described. The magnetic nanocomposite was synthesized and fully characterized using X-ray photoelectron

Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry.

Cheryl Brandenburg et al.

Frontiers in cellular neuroscience, 14, 577858-577858 (2020-11-27)

Autism spectrum disorder (ASD) is behaviorally defined and diagnosed by delayed and/or impeded language, stereotyped repetitive behaviors, and difficulties with social interactions. Additionally, there are disruptions in motor processing, which includes the intent to execute movements, interrupted/inhibited action chain sequences

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Global Trade Item Number

SKU	GTIN
L1011-10G	04061832091655
L1011-5G	04061833949139

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